Table 1.
Descriptive Statistics of Individual Biomarkers and Summary Allostatic Load Score among Women 40–59, NHANES 1999–2004 (n = 1,680)
| Biomarker | Range | Mean | 25% | 50% | 75% | Clinical Cutoffa |
|---|---|---|---|---|---|---|
| Cardiovascular markers | ||||||
| Systolic blood pressure (mm Hg) | 76–202 | 121.7 | 110 | 121 | 133 | ≥140 |
| Diastolic blood pressure (mm Hg) | 22–110 | 74.6 | 68 | 74 | 81 | ≥90 |
| Homocysteine (μmol/L) | 1.65–60.74 | 7.97 | 6.23 | 7.32 | 8.87 | --- |
| Pulse rate (bt/min) | 38–134 | 73.5 | 66 | 72 | 80 | ≥85 |
| Metabolic markers | ||||||
| Body mass index (kg/m2) | 14.70–66.44 | 28.78 | 23.36 | 27.45 | 32.99 | ≥25 |
| Glycosylated hemoglobin (%) | 4.0–14.6 | 5.45 | 5.10 | 5.30 | 5.60 | ≥7.0 |
| HDL (mg/dL) | 8–124 | 58.67 | 47 | 56 | 68 | <50 |
| Total cholesterol (mg/dL) | 85–410 | 208.62 | 183 | 206 | 256 | ≥240 |
| Inflammatory markers | ||||||
| Albumin (g/dL) | 2.9–5.3 | 4.24 | 4.00 | 4.20 | 4.40 | ≤3.5 |
| CRP (mg/dL) | 0.1–10.7 | 0.52 | 0.10 | 0.27 | 0.64 | ≥0.3 |
| Allostatic Load Score | 0–9 | 2.30 | 1 | 2 | 3 | --- |
For empirically-based AL score, 75% are the cutoff values and 25% for albumin and HDL.
Abbreviations: SD=standard deviation; mm=millimeter; Hg=mercurcy; μmol= micromole; L=liters; bt=beats; min=minutes; kg=kilogram; m2=meters squared; mg=millilgrams; dL=deciliter; g=grams.
a
Clinical cutoffs based on medical recommendations and guidelines for clinical high risk. There are no clinical high-risk standard for homocysteine.