Fig. 8.

A model for Wt1 and β-catenin regulation of mesothelial maintenance signaling necessary for proper differentiation of the posterior diaphragm mesenchyme. (A) A summary of the similarities and differences seen in the Wt1 null and Wt1^CreERT2;Bcat^fx mutant diaphragm phenotypes. (B) A schematic summarizes our findings comparing the dynamics of diaphragm differentiation in Wt1 null, β-catenin loss-of-function and gain-of-function embryos and proposes a mechanism that, when defective, results in the phenotypes observed.