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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Dev Biol. 2015 Aug 20;407(1):26–39. doi: 10.1016/j.ydbio.2015.08.010

Figure 7. Gbx2 act cell non-autonomously to regulate gene expression and cell proliferation.

Figure 7

(A-I) In situ hybridization on coronal sections of the thalamus of indicated genotypes between E12.5 and E13.5. (J-N) Immunostaining of Islr2 and Cntn2 on coronal sections of the E12.5 thalamus. Brackets demarcate the thalamus; red arrowheads indicate Islr2+, presumably Gbx2-deficient cells; white arrowheads indicate Islr2−, presumably wild-type cells. (O-W) Immunostaining of BrdU on coronal sections of E13.5 thalamus following 1-hour pulse labeling. The arrowhead indicates the abnormal gene expression and cell proliferation in Gbx2-KO thalamus; the asterisk shows the rescue in the thalamus that is composed of wild-type and Gbx2-deficient cells.