Table I.
Down-regulated genes due to the loss of Gbx2
| key | Symbol | Description | logFC | adj.P.Val | Expression | Verified |
|---|---|---|---|---|---|---|
| Combined | Cyp1b1 | cytochrome P450, family 1, subfamily b, polypeptide 1 | −3.0 | 0.004 | NA | |
| Array2 | Cops8 | COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana) | −2.7 | 0.020 | NA | |
| Combined | Id4 | inhibitor of DNA binding 4 | −2.5 | 0.003 | Yes | Yes |
| Array1 | Chst1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | −2.4 | 0.001 | Yes | Yes |
| Combined | Ntng1 | netrin G1 | −2.1 | 0.005 | Yes | Yes* |
| Array1 | Rbfox1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | −2.1 | 0.015 | Yes | |
| Combined | Kirrel3 | kin of IRRE like 3 (Drosophila) | −2.0 | 0.011 | Yes | |
| Combined | Glra2 | glycine receptor, alpha 2 subunit | −2.0 | 0.014 | Yes | Yes |
| Combined | Hs6st2 | heparan sulfate 6-O-sulfotransferase 2 | −1.9 | 0.004 | Yes | Yes |
| Array1 | Sertad4 | SERTA domain containing 4 | −1.9 | 0.002 | NA | IC |
| Array1 | C1ql2 | complement component 1, q subcomponent-like 2 | −1.9 | 0.027 | PTh | |
| Combined | Slc18a2 | solute carrier family 18 (vesicular monoamine), member 2 | −1.8 | 0.008 | Yes | Yes |
| Array2 | Gbx2 | gastrulation brain homeobox 2 | −1.8 | 0.044 | Yes | Yes** |
| Array1 | Hbb-b1 | hemoglobin, beta adult major chain | −1.8 | 0.086 | NA | |
| Combined | Calb2 | calbindin 2 | −1.8 | 0.005 | Yes | |
| Combined | Rora | RAR-related orphan receptor alpha | −1.8 | 0.013 | Yes | Yes |
| Array2 | Sema3a | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | −1.7 | 0.074 | Yes | |
| Combined | Nxph1 | neurexophilin 1 | −1.7 | 0.047 | Yes | |
| Array1 | Wif1 | Wnt inhibitory factor 1 | −1.6 | 0.028 | Yes | Yes* |
| Array1 | Ttc27 | tetratricopeptide repeat domain 27 | −1.6 | 0.026 | NA | |
| Array1 | Sulf2 | sulfatase 2 | −1.6 | 0.003 | ? | |
| Combined | Rit2 | Ras-like without CAAX 2 | −1.6 | 0.011 | Yes | |
| Array1 | Dlk1 | delta-like 1 homolog (Drosophila) | −1.6 | 0.046 | Yes | IC |
| Combined | Samd5 | sterile alpha motif domain containing 5 | −1.5 | 0.005 | Yes | |
| Array1 | Robo2 | roundabout homolog 2 (Drosophila) | −1.5 | 0.034 | Th | Yes** |
| Array2 | Tle1 | transducin-like enhancer of split 1, homolog of Drosophila E(spl) | −1.4 | 0.038 | PTh | |
| Array1 | Dab1 | disabled 1 | −1.3 | 0.007 | Yes | Yes* |
| Combined | Thsd7b | thrombospondin, type I, domain containing 7B | −1.3 | 0.015 | NA | |
| Combined | Sgk1 | serum/glucocorticoid regulated kinase 1 | −1.3 | 0.009 | Yes | |
| Combined | Syt13 | synaptotagmin XIII | −1.3 | 0.005 | Yes | |
| Array1 | Clmp | CXADR-like membrane protein | −1.3 | 0.025 | NA | |
| Array1 | Foxp2 | forkhead box P2 | −1.3 | 0.026 | Yes | Yes* |
| Combined | Gm10304 | predicted gene 10304 | −1.2 | 0.021 | ||
| Combined | Cd47 | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) | −1.2 | 0.030 | Yes | Yes |
| Combined | Ccng2 | cyclin G2 | −1.2 | 0.027 | NA | |
| Combined | Tenm4 | teneurin transmembrane protein 4 | −1.2 | 0.025 | Yes | |
| Array2 | Vegfc | vascular endothelial growth factor C | −1.2 | 0.053 | Yes | |
| Array1 | Lhfp | lipoma HMGIC fusion partner | −1.1 | 0.039 | Yes | |
| Combined | Chn2 | chimerin 2 | −1.1 | 0.024 | ||
| Array2 | Cfap69 | cilia and flagella associated protein 69 | −1.1 | 0.065 | No signals | |
| Combined | Fgfr1op2 | FGFR1 oncogene partner 2 | −1.1 | 0.023 | ||
| Combined | Pcdh9 | protocadherin 9 | −1.1 | 0.041 | Yes | |
| Array1 | Ednrb | endothelin receptor type B | −1.1 | 0.026 | No signals | |
| Array1 | Vcam1 | vascular cell adhesion molecule 1 | −1.1 | 0.061 | No signals | |
| Array2 | Enpp2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | −1.1 | 0.078 | ||
| Combined | Slc1a3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | −1.0 | 0.024 | Yes | |
| Combined | Atrnl1 | attractin like 1 | −1.0 | 0.027 | NA | |
| Array1 | Rnf152 | ring finger protein 152 | −1.0 | 0.041 | Yes | |
| Combined | Arpp21 | cyclic AMP-regulated phosphoprotein, 21 | −1.0 | 0.034 | Yes | |
| Combined | Sel1l3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | −1.0 | 0.011 | ||
| Combined | Rgs10 | regulator of G-protein signalling 10 | −1.0 | 0.044 | NA | |
| Array1 | Brat1 | BRCA1-associated ATM activator 1 | −0.9 | 0.028 | NA | |
| Array1 | Zfhx4 | zinc finger homeodomain 4 | −0.9 | 0.089 | No signals | |
| Array1 | Lxn | latexin | −0.9 | 0.032 | Yes (VZ) | |
| Array1 | Dner | delta/notch-like EGF-related receptor | −0.9 | 0.078 | Not specific | |
| Array1 | Celf2 | CUGBP, Elav-like family member 2 | −0.9 | 0.080 | Yes | |
| Array1 | Fam155a | family with sequence similarity 155, member A | −0.9 | 0.028 | No signals | |
| Array1 | Pmp22 | peripheral myelin protein 22 | −0.9 | 0.041 | NA | |
| Combined | Igsf21 | immunoglobulin superfamily, member 21 | −0.9 | 0.018 | Yes | |
| Array1 | Elmo1 | engulfment and cell motility 1 | −0.9 | 0.026 | Yes | |
| Combined | Glce | glucuronyl C5-epimerase | −0.9 | 0.033 | Yes | |
| Array1 | Dkk3 | dickkopf homolog 3 (Xenopus laevis) | −0.9 | 0.027 | Not specific | |
| Array1 | Tmem130 | transmembrane protein 130 | −0.9 | 0.096 | Not specific | |
| Array1 | Rapgef5 | Rap guanine nucleotide exchange factor (GEF) 5 | −0.9 | 0.028 | Yes | |
| Array1 | Tmem108 | transmembrane protein 108 | −0.9 | 0.030 | No signals | |
| Array1 | Limch1 | LIM and calponin homology domains 1 | −0.9 | 0.063 | No signals | |
| Combined | Epha3 | Eph receptor A3 | −0.9 | 0.046 | Yes | Yes |
| Combined | Gpr83 | G protein-coupled receptor 83 | −0.8 | 0.048 | weak signals | |
| Array1 | Arrdc3 | arrestin domain containing 3 | −0.8 | 0.036 | NA | |
| Combined | Prmt8 | protein arginine N-methyltransferase 8 | −0.8 | 0.025 | NA | |
| Array1 | E130114P18Ri RIKEN cDNA E130114P18 gene | −0.8 | 0.079 | NA | ||
| Array1 | Bcl11a | B cell CLL/lymphoma 11A (zinc finger protein) | −0.8 | 0.057 | Not specific | |
| Combined | Gas7 | growth arrest specific 7 | −0.8 | 0.033 | Yes | Yes |
| Array1 | Esrrb | estrogen related receptor, beta | −0.8 | 0.089 | PT | |
| Array1 | Chrna4 | cholinergic receptor, nicotinic, alpha polypeptide 4 | −0.8 | 0.041 | ET+PT | |
| Array1 | Efna5 | ephrin A5 | −0.8 | 0.057 | Yes 38/76 (50.0%) | Yes** 16/76 (21.1%) |