Table 1.
Association between season and eosinophilic esophagitis
| Study setting | Study population | Case definition | Case sample size (n) | Study design | Association |
|---|---|---|---|---|---|
| Single center study (St. John Hospital and Medical Center, Michigan, U.S.), 2001–2006 | Pediatric | ≥ 20 eos/hpf | 44 | Retrospective chart review | No significant difference in season of symptom onset or diagnoses |
| Single center (University of Iowa, Iowa, U.S.); 2003–2013 | Adolescent and adult | ≥ 20 eos/hpf | 193 | Retrospective review of administrative billing data | No significant difference in diagnoses by month or season |
| Single center study (James Whitcomb Riley Hospital for Children, Indiana, U.S.); 1998–2004 | Pediatric | ≥ 15 eos/hpf | 234 | Retrospective chart review | Increased diagnoses in Spring, Summer, and Fall as compared to Winter |
| Single center (Mayo Clinic, Minnesota, U.S.); 2000–2008 | Adult | ≥ 20 eos/hpf | 372 | Retrospective review of patients in EoE registry | Increased diagnoses in December/January and May/June |
| Single center (Mayo Clinic, Florida, U.S.); 2007–2008 | Adult | >20 eos/hpf | 41 | Retrospective review of pathology reports | Increased diagnoses in Spring and Summer as compared to Fall and Winter |
| Single center (University of North Carolina School of Medicine, North Carolina U.S.); 2000–2007 | Pediatric and adult | ≥ 15 eos/hpf | 151 | Retrospective case-control study from chart and endoscopic report review | Different distribution in season of diagnoses compared to GERD controls and increased diagnoses in Summer and Fall |
| Multisite (Medical University of Wroclaw, 10 regional centers, Poland); 2004–2009 | Pediatric | ≥ 15 eos/hpf | 84 | Retrospective review of pathology reports | Increased diagnoses in Spring and decreased diagnoses in Winter |
| Single center study (Marshall Health, Tri-state area, U.S.); 2003–2010 | Pediatric | ≥ 15 eos/hpf | 95 | Retrospective review of endoscopic reports | No significant difference in diagnoses by season |
| Single center study (NÄL Medical Centre, Sweden); 2004–2009 | Pediatric and adults | ≥ 15 eos/hpf | 24 | Retrospective chart review | Increased incidence of bolus impaction in EoE patients in Fall |