Table 2.

Association between Helicobacter pylori and eosinophilic esophagitis

Study setting	Study population	Case definition	Case sample size (n)	Study design	Association
National, U.S.-based study; 2008–2010	Pediatric and adult	≥ 15 eos/hpf as primary definition for EoE, H Pylori identified from gastric specimens	5,767	Cross-sectional, case control study of pathology data	Inverse association
Single center study (Shimane Institute of Health Science, Japan); 2010–2011	Adult	≥ 15 eos/hpf for EoE, H pylori established from serology testing	18	Matched, case control study	Inverse association
Single center study (Marshall Health, U.S.); 2007–2012	Pediatric	≥ 15 eos/hpf as primary definition for EoE, H Pylori identified from gastric specimens	62	Retrospective chart review	Inverse association
Von armin et al*	Adults	Histologically proven EoE (count unspecified), H pylori established from serology testing	58	Matched, case control study (abstract)	Inverse association
Multisite, Kalixanda study (Northern Sweden); 1998**	Adults	Presence of any esophageal eosinophils, H Pylori identified from gastric specimens	48	Cross sectional, prevalence study	Inverse association

^*Obtained from an abstract, no further details provided

^**Year authors report subjects were randomly selected from the general population