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. 2015 Nov 12;6:1258. doi: 10.3389/fmicb.2015.01258

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Copyright © 2015 Ode, Matsuda, Matsuoka, Hachiya, Hattori, Kito, Yokomaku, Iwatani and Sugiura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deep sequencing to detect minority viral populations. pNL4-3_wt and pNL101-based mutant clones (pNL101_rtK103N, pNL101_rtM184V, and pNL101_inQ148H) were mixed at seven different ratios: (a) 100:0:0:0, (b) 99.97:0.01:0.01:0.01, (c) 99.7:0.1:0.1:0.1, (d) 98.5:0.5:0.5:0.5, (e) 97:1:1:1, (f) 70:10:10:10, and (g) 40:20:20:20. The estimated frequencies of RT K103N, RT M184V, and IN Q148H are shown in orange circles, red squares, and black triangles, respectively.