Fig. 2. In muscle, adiponectin receptor 1 (AdipoR1) regulates peroxisome proliferator-activated receptor α (PPARα) coactivator-1 (PGC-1α) via AMP-activated protein kinase (AMPK)-sirtuin 1 (SIRT1) and Ca2+-calcium/calmodulin-dependent protein kinase kinase (CaMKK) pathways to promote mitochondrial biogenesis [31,34]. AdipoRon, adiponectin receptor agonist; NADH, nicotinamide adenine dinucleotide; CaMK, calcium/calmodulin-dependent protein kinase; LKB1, liver kinase B1.
