Table 4. Odds ratios (95% confidence interval) for the presence of coronary artery calcium score ≥400 and calcified, mixed, or noncalcified plaques according to serum total bilirubin level as a continuous variable after adjustments for confounding variables.
Variable | Serum total bilirubin (µmol/L) | P value |
---|---|---|
CAC score ≥400 | ||
Unadjusted | 0.771 (0.707-0.842) | <0.001 |
Model 1 | 0.761 (0.690-0.840) | <0.001 |
Model 2 | 0.735 (0.661-0.817) | <0.001 |
Model 3 | 0.718 (0.641-0.804) | <0.001 |
Calcified plaque | ||
Unadjusted | 0.943 (0.900-0.988) | 0.014 |
Model 1 | 0.957 (0.908-1.010) | 0.108 |
Model 2 | 0.952 (0.901-1.007) | 0.086 |
Model 3 | 0.955 (0.901-1.011) | 0.114 |
Mixed plaque | ||
Unadjusted | 0.880 (0.828-0.935) | <0.001 |
Model 1 | 0.878 (0.825-0.936) | <0.001 |
Model 2 | 0.887 (0.832-0.947) | <0.001 |
Model 3 | 0.886 (0.829-0.948) | <0.001 |
Noncalcified plaque | ||
Unadjusted | 0.902 (0.857-0.950) | <0.001 |
Model 1 | 0.911 (0.864-0.961) | 0.001 |
Model 2 | 0.917 (0.869-0.969) | 0.002 |
Model 3 | 0.916 (0.867-0.969) | 0.002 |
Model 1: adjusted for age, gender, duration of diabetes, hypertension, systolic blood pressure, diastolic blood pressure, and current smoking. Model 2: adjusted for all of the variables in model 1 plus body mass index, glycosylated hemoglobin, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglycerides. Model 3: adjusted for all of the variables in model 2 plus diabetic retinopathy and nephropathy, estimated glomerular filtration rate, current use of insulin and statin, aspartate aminotransferase, alanine aminotransferase, and alcohol intake.