Table 4. Odds ratios (95% confidence interval) for the presence of coronary artery calcium score ≥400 and calcified, mixed, or noncalcified plaques according to serum total bilirubin level as a continuous variable after adjustments for confounding variables.

Variable	Serum total bilirubin (µmol/L)	P value
CAC score ≥400
Unadjusted	0.771 (0.707-0.842)	<0.001
Model 1	0.761 (0.690-0.840)	<0.001
Model 2	0.735 (0.661-0.817)	<0.001
Model 3	0.718 (0.641-0.804)	<0.001
Calcified plaque
Unadjusted	0.943 (0.900-0.988)	0.014
Model 1	0.957 (0.908-1.010)	0.108
Model 2	0.952 (0.901-1.007)	0.086
Model 3	0.955 (0.901-1.011)	0.114
Mixed plaque
Unadjusted	0.880 (0.828-0.935)	<0.001
Model 1	0.878 (0.825-0.936)	<0.001
Model 2	0.887 (0.832-0.947)	<0.001
Model 3	0.886 (0.829-0.948)	<0.001
Noncalcified plaque
Unadjusted	0.902 (0.857-0.950)	<0.001
Model 1	0.911 (0.864-0.961)	0.001
Model 2	0.917 (0.869-0.969)	0.002
Model 3	0.916 (0.867-0.969)	0.002

Model 1: adjusted for age, gender, duration of diabetes, hypertension, systolic blood pressure, diastolic blood pressure, and current smoking. Model 2: adjusted for all of the variables in model 1 plus body mass index, glycosylated hemoglobin, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglycerides. Model 3: adjusted for all of the variables in model 2 plus diabetic retinopathy and nephropathy, estimated glomerular filtration rate, current use of insulin and statin, aspartate aminotransferase, alanine aminotransferase, and alcohol intake.