Table 4.

Logistic analysis of the risk factors for thyroid dysfunction

Variable	Univariate analysis			Multivariate analysis
	OR	95% CI	p value	OR	95% CI	p value
Female sex	1.317	0.749–2.316	0.339
Age	0.985	0.963–1.007	0.186
Body mass index	1.052	0.953–1.161	0.319
Liver cirrhosis	0.660	0.297–1.468	0.309
Type of therapy
PEG-IFNα-2a	Reference			Reference
PEG-IFNα-2b	1.950	1.094–3.473	0.023	3.019	1.426–6.390	0.004
Thyroid stimulating hormonea	3.025	1.685–5.428	< 0.001	2.088	1.961–8.767	< 0.001
Anti-TPO Ab+	9.571	2.477–36.989	0.001	8.812	1.742–44.577	0.009
Anti-TG Ab+	4.912	1.528–15.812	0.008	2.389	0.564–10.124	0.237

OR, odds ratio; CI, confidence interval; PEG-IFN, pegylated interferon; Anti-TPO Ab, anti-thyroid peroxidase antibody; Anti-TG Ab, anti-thyroglobulin antibody.

^a≤ 2.03 mIU/mL vs. > 2.03 mIU/mL.