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. 2015 Nov 12;9:303. doi: 10.3389/fnbeh.2015.00303

Figure 2.

Figure 2

Environmental enrichment increases glucocorticoid receptor (GR) levels after chronic + acute stress. (A) Cytosolic GR increased significantly for both ST- and EE-housed animals after acute stress compared to controls of the same housing condition (#p < 0.01). Both ST- and EE-housed animals showed a significant decrease in cytosolic GR levels after chronic stress compared to acute stress treatment of the same housing condition (!p < 0.01). Chronic + acute stress in EE-housed animals showed a significant increase in cytosolic GR compared to ST-housed animals for the same treatment (**p < 0.01) and compared to chronic stress for EE housed animals (∧p < 0.01). Chronic + acute stress for both ST- and EE-housed animals significantly increased cytosolic GR compared to controls in the same housing conditions (#p < 0.01). (B) Synaptic GR significantly increased after chronic + acute stress for EE housed animals compared to all other treatments within the same housing condition (∧p < 0.01) and compared to ST chronic + acute (**p < 0.01).