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. 2015 Nov 12;9:303. doi: 10.3389/fnbeh.2015.00303

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Copyright © 2015 Zanca, Braren, Maloney, Schrott, Luine and Serrano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Environmental enrichment decreases PKMζ levels after acute stress and after chronic + acute stress. (A) ST chronic is significantly increased compared to EE chronic (*p < 0.05) and ST chronic + acute is significantly increased compared to EE chronic + acute (*p < 0.05). (B) ST chronic + acute stress significantly increased synaptic PKMζ levels compared to EE chronic (^∧p < 0.01), ST chronic (^∧p < 0.01) and EE chronic + acute (**p < 0.01). EE control significantly increased synaptic PKMζ compared to ST control (**p < 0.01) and compared to EE acute (^#p < 0.01). ST acute had significantly increased synaptic PKMζ compared to EE acute (*p < 0.05) and compared to ST control (^#p < 0.05).