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. 2015 Oct 15;192(8):998–1008. doi: 10.1164/rccm.201410-1820OC

Figure 2.

Figure 2.

Mice exposed to Schistosoma mansoni eggs develop pulmonary hypertension and vascular remodeling, which is suppressed in the absence of IL-4 and IL-13. (A) Right ventricular systolic pressure (RVSP) of intraperitoneal and intravenous (IP/IV) egg–exposed mice (mean ± SD; n = 9–18 mice per group; analysis of variance (ANOVA), P = 0.01; post hoc Tukey test, *P < 0.05, **P < 0.01). (B) Fulton index (RV/[LV + S]) of IP/IV egg–exposed mice (mean ± SD; n = 9–18 mice per group; ANOVA, P = 0.001; post hoc Tukey test, *P < 0.05, ****P < 0.001). (C) Periegg granuloma volumes in IP/IV egg–exposed mice (mean ± SD; n = 9–18 mice per group; ANOVA, P = 0.03; post hoc Tukey test, *P < 0.05). (D) Quantitative fractional thickness of the pulmonary vascular media in IP/IV egg exposed mice (mean ± SD; n = 9–18 mice per group; ANOVA P = 0.007; post hoc Tukey test, *P < 0.05, **P < 0.01). LV = left ventricle; RV = right ventricle; S = systolic; WT = wild type.