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Roflumilast therapy does not affect systemic proline-glycine-proline (PGP). There were no statistical differences in plasma (A) acetyl-proline-glycine-proline (AcPGP) and (B) PGP, suggesting the antiinflammatory effect is most pronounced in the lung. Open bars represent the placebo group (n = 16), and solid bars represent the roflumilast group (n = 11). Values expressed as mean ± SEM. NS = not significant.
