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. 2015 Nov 12;5:16552. doi: 10.1038/srep16552

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Copyright © 2015, Macmillan Publishers Limited

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(a) LX-2 cells were co-tranfected with pGL3-Basic vector containing human CD147 promoter (−1761/+37) and pReceiver-M02-Smad4, CD147 promoter activity was detected by dual-luciferase reporter assay. (b) LX-2 cells were co-transfected with different length of CD147 promoters and pReceiver-M02-Smad4, CD147 promoter activity was detected by dual-luciferase reporter assay. (c) Schematic representation of wild type (Wt) and mutant (Mut) CD147 promoter regions. (d) LX-2 cells were co-tranfected with Wt CD147 or Mut CD147 promoters and pReceiver-M02-Smad4, CD147 promoter activity was detected by dual-luciferase reporter assay. (e) LX-2 cells were treated with TGF-β1 and subjected to ChIP assay. Positive control was anti-RNA polymerase. Two percent of the lysate was used as the input control. *P < 0.05.