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. 2015 Nov 12;5:16552. doi: 10.1038/srep16552

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(a) Immunohistochemistry analysis of CD147 and TGF-β1 expressions in liver tissues from 6-month-old C57BL/6 and HBV-tg mice. (b) Double immunofluorescence of TGF-β1 (red), CD147 (red), and α-SMA (green) in liver tissues from 6-month-old C57BL/6 and HBV-tg mice. Cell nuclei were stained with DAPI. (c) Western blot analysis of CD147, TGF-β1, p-Smad2, Smad2, p-Smad3, Smad3, Smad4, ERK1/2, p-ERK1/2, and Sp1 in liver tissues from 6-month-old C57BL/6 and HBV-tg mice. (d) Immunohistochemistry and (e) real-time RT-PCR analysis of TGF-β1 expression in liver tissues from CCl₄-induced mice after treatment with CD147-specific antibody HAb18. n = 7. (f) Schematic model of TGF-β1-CD147 positive feedback loop in HSC activation.