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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Neurobiol Dis. 2015 Jun 30;82:281–288. doi: 10.1016/j.nbd.2015.06.017

Fig.1.

Fig.1

UBQLN2 localizes to polyglutamine inclusions in HD-KI (Q200) mice but not SCA3-KI mice. Immunohistochemistry with anti-HTT (A-D) or anti-UBQLN2 (E-H, Q-T) antibody was performed on brain sections from 75-week-old HD-KI (Q200) mice (A-H) or WT littermates (Q-T). HD-KI (Q200) mice show robust inclusions in the indicated brain regions that often co-immunostain positively for UBQLN2. Immunohistochemistry with anti-ATXN3 1H9 (I-L) or anti-UBQLN2 (M-P) antibody was performed on brain sections from 52-week-old SCA3 KI mice. ATXN3 inclusions in SCA3-KI mice do not coimmunostain for UBQLN2. Scale bars = 20 μm.