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. 2015 Nov 12;5:16555. doi: 10.1038/srep16555

Figure 8. A proposed working model for HPV16 E6/E7 and LiCl regulating GSK3β in cervical cancers.

Figure 8

HPV16 E6 and/or E7 up-regulate GSK3β transcription and may also play a role in GSK3β mRNA stability and translation. LiCl is known to increase the phosphorylation of GSK3β at Ser9 and increases GSK3β mRNA level in a HPV16 E6/E7-dependent manner in CaSki cells. Inline graphic indicates the positive effects reported previously or in this report; Inline graphic indicates the relationships that are postulated but have not been established.