Figure 8. A proposed working model for HPV16 E6/E7 and LiCl regulating GSK3β in cervical cancers.
HPV16 E6 and/or E7 up-regulate GSK3β transcription and may also play a role in GSK3β mRNA stability and translation. LiCl is known to increase the phosphorylation of GSK3β at Ser9 and increases GSK3β mRNA level in a HPV16 E6/E7-dependent manner in CaSki cells. indicates the positive effects reported previously or in this report;
indicates the relationships that are postulated but have not been established.