Table 2.
Studies comparing young lung cancer patients to older patients with sample size of more of 100 patients: data about clinico-pathologic features.
| N (% of total) | Country, Year | Age cut-off | Smoking status* | Cancer cases in family | % of females | Histological type | Stage | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Young (%) | Old (%) | P | Young (%) | Old (%) | P | Young (%) | Old (%) | P | Young (%) | Old (%) | P | Young (%) | Old (%) | P | ||||
| Roviaro, 1985 [2] | 155 (10%) | Italy, 1967–1980 | <45 years | Smokers 93% | NA | NA | NA | 8% | NR | NS | AC 18% SQ 64% |
NR | NS | Stage I–III 92% Stage IV 8% |
Stage I–III 96% Stage IV 4% |
NS | ||
| McDuffie, 1989[3] | 187 (7%) | Saskat-chewan (CA), 1979–1986 | ≤50 years | Smokers 85% | Smokers 78% | NS | One first-degree relative with LC | 46% | 22% | P<0.001 | NR | P<0.005 | NA | |||||
| 7.5% | 6% | NS | ||||||||||||||||
| Ramalingam, 1998 [4] | 2804 (9%) | Metropolitan Detroit SEER registry, 1973–1992 | <50 years | NA | NA | 40% | 31% | P<0.001 | AC 46% SQ 27% |
AC 34% SQ 38% |
P<0.001 | Local 19% Distant 53% |
Local 25% Distant 49% |
P<0.001 | ||||
| Kreuzer, 1998 [5] | 251 | Germany, 1990–1996 | ≤45 years | Smokers 95% | Smokers 94% | NA | One first-degree relative with LC | 27% | 15% | NA | AC 42% SQ 24% |
AC 31% SQ 39% |
P=0.3 | NA | NA | NA | ||
| 10% | 7% | NA | ||||||||||||||||
| Kuo, 2000 [6] | 127 (2%) | Taiwan, 1987–1996 | <40 years | NA | NA | 52% | NR | P<0.001 | AC 61% SQ 21% |
NR | P=0.0004 | Stage I 9% Stage IV 47% |
Stage I 15% Stage IV 40% |
NS | ||||
| Radzikowska, 2001 [7] | 757 (14%) | Poland, 1995 | ≤50 years | Smokers 76% | Smokers 77% | P=0.349 | Cancer cases in family (mother and father) | 24% | 12% | P<0.001 | AC 13% SQ 35% |
AC 8% SQ 42% |
P<0.001 | Stage I 24% Stage IV 19% |
Stage I 23% Stage IV 15% |
P=0.059 | ||
| P<0.001 | ||||||||||||||||||
| Mauri, 2006 [8] | 115 (6%) | Greece, 1989–2004 | ≤45 years | Smokers 77% | Smokers 75% | P=0.326 | NA | 18% | 12% | P=0.071 | AC 49% SQ 24% |
AC 43% SQ 37% |
P=0.004 | Stage IV 12% | Stage IV 22% | P=0.016 | ||
| Subramanian, 2010 [9] | 2775 (1%) | SEER registry, 1988–2003 | ≤40 years | NA | NA | 49% | 42% | P<0.0001 | AC 58% SQ 13% |
AC 45% Q 26% |
P<0.0001 | Stage I 12% Stage IV 57% |
Stage I 21% Stage IV 43% |
P<0.0001 | ||||
| Inoue, 2014 [10] | 704 (6%) | Japan, 2004 | ≤50 years | Smokers 47% | Smokers 57% | P<0.001 | NA | 47% | 37% | P<0.001 | AC 79% SQ 7% |
AC 67% SQ 23% |
P<0.001 | Stage I 64% Stage III–IV 24% |
Stage I 65% Stage III–IV 20% |
P<0.001 | ||
| Rich, 2015 [11] | 651 (0.4%) | English National Lung Cancer Audit, 2004–2011 | 18–39 years | NA | NA | 44% | 43% | NR | AC 48% SQ 13% |
AC 33% SQ 33% |
NR | Stage I 9% Stage IIIB–IV 71% |
Stage I 14% Stage IIIB–IV 61% |
NR | ||||
*
Smokers (current smokers and exsmokers) versus Nonsmokers. NA – not assessed; NS ,– not significant; NR – not reported; LC – lung cancer; SEER – surveillance, epidemiology, and end results; AC – adenocarcinoma; SQ – squamous cell carcinoma