Table 3.

Studies comparing young lung cancer patients to older patients with sample size of more of 100 patients: data about patients’ outcome.

	1-year OS rate			5-year OS rate			OS
	Young	Old	P	Young	Old	P	Young	Middle-age	Old	P
Roviaro, 1985 [2]		NA		21%	25%	NS			NA
Ramalingam, 1998 [4]		NA		16%	13%	P<0.001			NA
Kuo, 2000 [6]		NA			NA		9 months	8 months	4 months	P<0.0001
Radzikowska, 2001 [7]	33%	29%	P<0.049		NA			NR		P=0.01107
Mauri, 2006 [8]		NA			NA		12 months	NA	11.5 months	P=0.277
Subramanian, 2010 [9]		NA			NA		Younger patients had better stage-wise overall and disease-specific survival than older patients			P<0.0001
Inoue, 2014 [10]		NA		79%	69%	P<0.001	NA
Rich, 2015 [11]		NA			NA		Young patients had a lower overall mortality than older patients (62% vs. 86%, respectively)			P<0.001

OS – overall survival; NA – not assessed; NS – not significant; NR – not reported.