TABLE 2.
Premenopausal |
Postmenopausal |
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First author, year (ref) | Age, y | Study design | Country | Contrast | Cases/noncases, n | Risk estimate | 95% CI | Cases/noncases, n | Risk estimate | 95% CI |
Recent BMI | ||||||||||
Okobia, 2006 (65) | Not specified | HCC | Nigeria | Above vs. below median2 | 142/not specified | 0.82 | 0.49, 1.36 | 108/NS | 0.76 | 0.44, 1.32 |
Nemesure, 2009 (67) | ≥21 | PCC | Barbados | ≥30 vs. < 25 | 77/1653 | 0.44 | 0.19, 1.01 | 142/2864 | 0.70 | 0.38, 1.28 |
Ogundiran, 2010 (66)5 | ≥18 | PCC | Nigeria | ≥28 vs. < 21 | 682/819 | 0.70 | 0.50, 0.98 | 505/278 | 0.76 | 0.48, 1.21 |
WHR | ||||||||||
Okobia, 2006 (65) | Not specified | HCC | Nigeria | Above vs. below median2 | 142/not specified | 2.566 | 1.48, 4.41 | 108/not specified | 2.06 | 1.10, 3.64 |
Nemesure, 2009 (67) | ≥21 | PCC | Barbados | ≥0.85 vs. < 0.80 | 76/1653 | 0.86 | 0.37, 1.98 | 143/2864 | 2.17 | 1.02, 4.60 |
Ogundiran, 2012 (70)5 | ≥18 | PCC | Nigeria | ≥0.87 vs. < 0.77 | 702/819 | 2.127 | 1.49, 2.99 | 518/278 | 2.267 | 1.39, 3.68 |
HCC, hospital-based case-control study; PCC, population-based case-control study; ref, reference; WHR, waist-to-hip ratio.
Dichotomized variable based on means for controls: premenopausal women: BMI:24.83 kg/m2, WHR: 0.88; postmenopausal women: BMI: 25.03 kg/m2, WHR: 0.90.
Age < 50 y (unknown menopausal status).
Age ≥50 y (unknown menopausal status).
Adebamowo et al. (68, 69) were earlier reports for Ogundiran et al. (66, 70) and were therefore not included in the table because they correspond to the same study.
Adjusted for age only.
Further adjusted for BMI.