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. 2015 Nov 11;6:212. doi: 10.1186/s13287-015-0214-y

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© Katsuda and Ochiya. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of therapeutic effects mediated by MSC-EVs. MSC-EVs can support the recovery of injured organs, and this supportive effect is dependent on EV content molecules. In this article, content molecule-dependent therapeutic effects are classified into three categories: protein-mediated effects, RNA-mediated effects, and undefined molecule-mediated effects (summarized in Tables 1, 2 and 3, respectively). EV extracellular vesicle, MSC mesenchymal stem cell