Table 2.
Association with obesity: Case–control analysis in GOYA (male) and TDCOB study participants
| SNP | Locus | Alleles (effect/other) | GOYA (n = 1461) | TDCOB (n = 1672) | Combined (n = 3133) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n (cases/controls) | EAF (cases/controls) | p | OR (95 % CI) | n (cases/controls) | EAF (cases/controls) | p | OR (95 % CI) | n (cases/controls) | p | OR (95 % CI) | I2 (p HET) | |||
| rs2069845 | IL6 | G/A | 739/722 | 0.49/0.49 | 0.88 | 0.98 (0.85–1.14) | 1022/650 | 0.47/0.49 | 0.13 | 0.88 (0.76–1.01) | 1761/1372 | 0.24 | 0.94 (0.85–1.04) | 0 (0.35) |
| rs1137100 | LEPR | A/G | 739/722 | 0.74/0.74 | 0.69 | 0.96 (0.81–1.14) | 1022/650 | 0.75/0.74 | 0.42 | 1.05 (0.90–1.23) | 1761/1372 | 0.46 | 1.01 (0.90–1.14) | 0 (0.40) |
| rs3801266 | NAMPT | T/C | 739/722 | 0.82/0.83 | 0.96 | 0.99 (0.82–1.20) | 1022/650 | 0.83/0.84 | 0.47 | 0.92 (0.76–1.11) | 1761/1372 | 0.58 | 0.96 (0.84–1.10) | 0 (0.63) |
| rs2796749 | AMD1 | G/C | 739/722 | 0.78/0.78 | 0.94 | 1.0 (0.84–1.19) | 1022/650 | 0.79/0.78 | 0.59 | 1.03 (0.87–1.22) | 1761/1372 | 0.68 | 1.02 (0.90–1.15) | 7 (0.73) |
Cases and controls were defined using age and sex-specific cut-offs corresponding to a BMI ≥25 kg/m2 in adults. p-values are for an additive genetic model and are adjusted for age
EAF Effect allele frequency, BMI body mass index, CI confidence interval, HET heterogeneity, OR Odds Ratio, SNP single nucleotide polymorphism