Table 3.

Association with quantitative traits in 1372 normal weight individuals

SNP	Locus	Alleles (effect/other)	Effect allele frequency	GOYA (n = 722)			TDCOB (n = 650)			Combined (n = 1372)
				β	SE	p	β	SE	p	β	SE	p	I 2 (p HET)
zBMI
rs2069845	IL6	G/A	0.49	0.04	0.05	0.34	−0.02	0.05	0.62	0.01	0.04	0.76	3 (0.31)
rs1137100	LEPR	A/G	0.74	−0.17	0.06	0.0036	−0.08	0.06	0.15	−0.12	0.04	0.0026	20 (0.26)
rs3801266	NAMPT	T/C	0.83	−0.03	0.07	0.58	0.04	0.07	0.51	0.01	0.05	0.93	0 (0.39)
rs2796749	AMD1	G/C	0.78	0.03	0.06	0.60	−0.16	0.06	0.0077	−0.06	0.04	0.12	80 (0.03)
zHeight
rs2069845	IL6	G/A	0.49	0.02	0.05	0.65	−0.07	0.06	0.19	−0.02	0.04	0.56	36 (0.20)
rs1137100	LEPR	A/G	0.74	0.01	0.06	0.63	−0.08	0.06	0.17	−0.04	0.04	0.36	5 (0.30)
rs3801266	NAMPT	T/C	0.83	0.07	0.07	0.32	−0.12	0.08	0.12	−0.02	0.05	0.75	69 (0.07)
rs2796749	AMD1	G/C	0.78	−0.12	0.06	0.046	0.10	0.07	0.15	−0.02	0.05	0.64	82 (0.01)
zWeight
rs2069845	IL6	G/A	0.49	0.06	0.05	0.29	−0.05	0.03	0.047	−0.03	0.02	0.19	69 (0.06)
rs1137100	LEPR	A/G	0.74	−0.14	0.06	0.017	−0.02	0.03	0.44	−0.05	0.03	0.08	68 (0.07)
rs3801266	NAMPT	T/C	0.83	0.02	0.07	0.82	−0.01	0.04	0.79	−0.01	0.03	0.89	0 (0.75)
rs2796749	AMD1	G/C	0.78	−0.07	0.06	0.29	−0.01	0.03	0.95	−0.01	0.03	0.66	0 (0.33)

Effect sizes (β), standard error (SE) and p-values are for an additive genetic model based on z-scores of each trait and are adjusted for age. Effect allele frequency is the mean frequency observed for the GOYA and TDCOB cohort control individuals. P _add < 0.05 is significant and is shown in bold. Values of I ² are percentages

BMI body mass index, CI confidence interval, HET heterogeneity, SE standard error, SNP single nucleotide polymorphism