Fig. 1.

Reduced amyloid pathology and reduced Aβ levels in 8 month-old PSAPP/Rag2 ko mice in comparison to age-matched PSAPP mice. a, b Quantitative analysis of Thioflavin S stainings shows a 25 % reduction in amyloid load and amyloid plaque number in the B and T cell-ablated PSAPP/Rag2 ko mice as compared to the PSAPP mice with a functional adaptive immune system (representative images of cortical stainings are shown in (a)). Scale bar = 300 μm. ***p < 0.001. n = 13–15 per group. c Quantitative MSD analysis of Aβ40 and Aβ42 in plasma and cortical brain extracts shows a significant reduction in Tris soluble, SDS detergent soluble and formic acid soluble Aβ40 and Aβ42 levels in the PSAPP/Rag2 ko mice as compared to the PSAPP mice. The reduction in brain Aβ levels is accompanied by a significant increase in plasma Aβ42. *p < 0.05. **p < 0.01. ***p < 0.001. n = 9–14 per group