Table 1.
Patient clinical characteristics, medication use and laboratory parameters, overall and by the presence of abdominal calcification
| Total | ACI Score = 0 | ACI Score >0 | p-value | |
|---|---|---|---|---|
| (n = 64) | (n = 22) | (n = 42) | ||
| Demographics & Clinical features | ||||
| Age (years), mean (sd) | 47.3 (13.0) | 35.8 (8.5) | 52.3 (9.6) | 0.001 |
| Male: n (%) | 39 (61 %) | 18 (75 %) | 21 (52 %) | 0.07 |
| Dialysis Modality: | 0.95 | |||
| Haemodialysis | 39 (60.9 %) | 15 (62.5 %) | 24 (60 %) | |
| Peritoneal dialysis | 23 (35.9 %) | 8 (33.3 %) | 15 (37.5 %) | |
| None (Pre-emptive) | 2 (3.2 %) | 1 (4.2 %) | 1 (2.5 %) | |
| Duration of dialysis (years), | 2.3 | 1.6 | 3.0 | 0.03 |
| Median (IQR) | (1.6, 3.3) | (0.8, 2.0) | (1.7, 3.8) | |
| Duration of Transplant (years), | 3.7 | 3.2 | 4.1 | 0.40 |
| Median (IQR) | (0.9, 8.1) | (0.9, 8.8) | (0.9, 7.1) | |
| Mean Arterial BP (mm Hg), Mean (sd) | 102.7 (9.7) | 100.0 (8.8) | 104.7 (8.9) | 0.01 |
| Body Mass Index (Kg/m2) | 25.6 | 23.7 | 26.0 | 0.16 |
| Median (IQR) | (22.8, 30.0) | (22.1, 29.3) | (23.4, 30.1) | |
| Diabetes: N (%) | 10 (15.6 %) | 3 (12.5 %) | 7 (17.5 %) | 0.60 |
| Ever Smoked: N (%) | 28 (43.8 %) | 8 (33.3 %) | 20 (50 %) | 0.19 |
| Prior parathyroidectomy N (%) | 8 (12.5 %) | 3 (12.5 %) | 5 (12.5 %) | 1.0 |
| Past History CV event: N (%) | 6 | 0 | 6 | 0.05 |
| Current Medication Use | ||||
| Tacrolimus: N (%) | 56 (87.5 %) | 21 (87.5 %) | 35 (87.5 %) | 1.0 |
| Mycophenolate mofetil: N (%) | 52 (81.2 %) | 17 (70.8 %) | 35 (87.5 %) | 0.10 |
| Corticosteroid, N (%) | 28 (43.8 %) | 10 (41.7 %) | 18 (45 %) | 0.80 |
| Vitamin D: N (%) | 5 | 1 | 4 | 0.64 |
| Laboratory parameters | ||||
| eGFR (ml/min per1.73 m2) mean (sd) | 54.1 (17.6) | 57.8 (14.8) | 48.3 (14.9) | 0.002 |
| iPTH (ng/ml), median (IQR) | 91.5 (73,108) | 106.5 (83.5, 75.0) | 86.5 (57,128) | 0.85 |
| Alkaline Phosphatase | 106.2 (50.7) | 106.5 (38.3) | 106.0 (57.3) | 0.97 |
| Serum calcium (mmol/L), mean (sd) | 2.57 (0.17) | 2.52 (0.16) | 2.63 (0.17) | 0.06 |
| Serum Phosphate (mmol/L), mean (sd) | 1.01 (0.22) | 1.00 (0.24) | 1.02 (0.21) | 0.70 |
| Serum Cholesterol (mmol/L), Mean (sd) | 4.7 (1.1) | 4.2 (0.9) | 5.0 (1.0) | 0.006 |
| Serum LDL Cholesterol (mmol/L), mean (sd) | 2.65 (0.91) | 2.34 (0.78) | 2.82 (0.94) | 0.06 |
| Serum HDL Cholesterol (mmol/L), mean (sd) | 1.35 (0.40) | 1.28 (0.35) | 1.39 (0.42) | 0.36 |