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. 2015 Sep 15;5:14044. doi: 10.1038/srep14044

Figure 4. Relationships between time in LL, behavioral rhythmicity and SCN cellular synchrony for WT and Vipr2−/− mice.

Figure 4

Vipr2−/− data describe a three-way positive correlation between increasing time in LL, greater behavioral rhythmicity and increasing SCN cellular synchrony (d–f). For WT mice, behavioral rhythmicity positively correlates with SCN cellular synchrony (c). Conversely, the relationships of both of these parameters with time in LL for WT mice are poorly fit by linear trends (broken lines on panels a,b) but ultimately result in a progressive decrease in both rhythmicity (a) and synchrony (b) after extended (>29 days) durations of LL (light unbroken lines added for visual reference; though see main text for statistical assessment of these subsets of data for >29 days in LL). Data in panels c–f are shown fitted with linear trend lines (heavy unbroken lines) that provided high goodness of fit and illustrate a linear relationship of ranked data in each case (all data sets in panels (c–f) show significant correlations; Spearman’s rho = 0.755 (p = 0.0025) (c), 0.522 (p = 0.038) (d), 0.6 (p = 0.007) (e) and 0.512 (p = 0.0215) (f)).