Table 2.
Demographic and Clinical Characteristics of 506 Older Participants, by NSNA
| Characteristic | NSNA, No. of Participantsa | P Value | ||||
|---|---|---|---|---|---|---|
| 0 (n = 208) |
1 (n = 131) |
2 (n = 96) |
3 (n = 38) |
<4 (n = 33) |
||
| Age, yb | 71.2 ± 0.4 | 71.2 ± 0.4 | 73.7 ± 0.5 | 73.9 ± 1.1 | 78.1 ± 1.2 | <.001 |
| Women, No. (%) | 113 (54.3) | 77 (58.8) | 54 (56.3) | 26 (68.9) | 17 (51.5) | .52 |
| ICEDc | 6.5 ± 0.2 | 7.1 ± 0.3 | 7.5 ± 0.3 | 7.5 ± 0.5 | 7.6 ± 0.5 | .08 |
| MMSE scorec | 26.9 ± 0.1 | 26.8 ± 0.2 | 26.7 ± 0.2 | 26.4 ± 0.3 | 25.6 ± 0.4 | .003 |
| GDS scorec | 6.6 ± 0.4 | 8.6 ± 0.6 | 8.0 ± 0.6 | 8.9 ± 1.0 | 8.9 ± 1.0 | .047 |
| SPPB scorec | 9.8 ± 0.1 | 9.5 ± 0.1 | 9.5 ± 0.1 | 8.9 ± 0.1 | 7.4 ± 0.1 | <.001 |
| 6-MWTc | 344 ± 91 | 326 ± 79 | 311 ± 91 | 306 ± 90 | 253 ± 93 | <.001 |
| BADLs, No. with dependencyb | 0.02 ± 0.02 | 0.05 ± 0.03 | 0.07 ± 0.04 | 0.06 ± 0.05 | 0.06 ± 0.06 | .50 |
| IADLs, No. with dependencyb | 0.3 ± 0.08 | 0.4 ± 0.10 | 0.6 ± 0.11 | 0.6 ± 0.16 | 1.4 ± 0.21 | <.001 |
Abbreviations: 6-MWT, walking distance during a 6-minute walking test; BADL, basic activity of daily living; IADL, instrumental activity of daily living; GDS, Geriatric Depression Scale; ICED, Index of Coexistent Diseases; MMSE, Mini-Mental State Examination; NSNA, number of subtle neurological abnormalities; SPPB, Short Physical Performance Battery score.
a
Data are given as mean ± SEM except where noted.
b
Unadjusted means from analysis of variance models.
c
Means adjusted for age and sex from analysis of covariance models.