Figure 4.
The clinical course of two patients who were weaned off of all immunosuppressive therapy. Shown for both patients is the immunosuppressive therapy received by month, receipt of bone marrow, deviation from the base regimen, duration and type of all episodes of viremia, results of all biopsies, any occurrence of DSA, and creatinine, maintenance therapy and presence of DSA or viremia at last follow-up beginning from the 1 year time point post transplantation (initiation of initial weaning). Dotted lines refer to viremia defined as low positive (present at the limit of the clinical assay) whereas solid lines refer to viremia occurring in the quantifiable range. The scalpel icon indicates a surgical procedure (in this case total knee replacement) performed after transplantation. See pictorial key for details.