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. 2015 Nov 15;26(23):4236–4247. doi: 10.1091/mbc.E15-05-0289

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© 2015 Ichikawa et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — Model of the LC1 localization within the γ head domain and the axoneme. (A) Previous model of LC1 localization. Two copies of LC1 were assumed to bind to the AAA+ ring of the γ head domain. Inside the axoneme, LC1 was presumed to tether the AAA+ ring to the A-tubule of DMT. The model was adopted from Patel-King and King (2009). (B) A new model of LC1 localization. One copy of LC1 is believed to locate on the γ MTBD region with its N-terminus oriented toward the tip and C-terminus toward the base. In this model, LC1 interacts with the B-tubule of the DMT together with the γ MTBD inside the axoneme. LC1 is likely to regulate OAD activity by modulating the affinity of the γ MTBD for the B-tubule. Note that the LC1-binding site within the MTBD region was not determined in this study.