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Active sites of human Pol γ (left) and HIV-RT (right). The nucleotide binding site of the two enzymes are different: In Pol γ: it is likely bounded by E895, Y951, Y955, and Q1102, whereas in HIV RT the binding site is bounded by R72, F77, Y115, and Q151. The difference provides exploitable space for more potent and specific antiviral drug design.
