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Preparation of phenyl substituted 4-anilidopiperidine analogues.
Reagents and conditions: (a) Na(OAc)3BH, Na2SO4, DCM, 12h; (b) Propionyl chloride, Et3N, DCM, 0 °C to room temperature, 4h; (c) 1-Chloroethyl chloroformate, 70 °C, DCE, 2h; (d) MeOH, reflux temperature; (e) K2CO3, acetone, 4h; (f) 50% TFA in DCM, 0 °C to room temperature.
