Table 3.

Receptor agonists and antagonists that modulate the electrophysiological effects of 5-HT_2A activation in the mPFC also alter the head twitch response in rats and mice.

Receptor	Ligand pharmacology	5-HT2A-induced sEPSCs in layer V pyramidal neurons1	DOI-induced head twitch response1
5-HT2A	antagonist	↓ M100907 Aghajanian & Marek, 1997 Beique et al., 2007 Benneyworth et al., 2007	↓ M100907 Schreiber et al., 1995
5-HT2C	antagonist	Ø SB242084 Marek & Aghajanian, 1999 Beique et al., 2007	Ø SB242084 Vickers et al., 2001 Fantegrossi et al., 2010
AMPA	antagonist	↓ LY293558 Aghajanian & Marek, 1997 Zhang & Marek, 2008 ↓ LY300164 Zhang & Marek, 2008) ↓ CNQX Klodzinska et al., 2002 Beique et al., 2007 Benneyworth et al., 2007	↓ LY293558 Zhang & Marek, 2008 ↓ GYKI 52466 Zhang & Marek, 2008 ↓ DNQX Gorzalka et al., 2005 ↓ NBQX Egashira et al., 2011
μ-opioid	agonist	↓ DAMGO Marek & Aghajanian, 1998 ↓ endomorphin-1 Marek & Aghajanian, 1998	↓ morphine Rojas-Corrales et al., 2007 ↓ buprenorphine Marek, 2003 ↓ fentanyl Marek, 2003
mGlu2/3	agonist	↓ LY354740 Marek et al., 2000 ↓ LY379268 Marek et al., 2000 Klodzinska et al., 2002	↓ LY354740 Gewirtz and Marek, 2000 Klodzinska et al., 2002) ↓ LY379268 Klodzinska et al., 2002
	antagonist	↑ LY341495 Marek et al., 2000	↓ LY341495 Gewirtz and Marek, 2000
Adenosine A1	agonist	↓ N6-cyclopentyladenosine Stutzmann et al., 2001	↓ N6-cyclohexyladenosine Marek et al., 2009

CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione; DAMGO, [D-Ala², N-MePhe⁴, Gly-ol⁵]-enkephalin; DNQX, 6,7-dinitroquinoxaline-2,3-dione; NBQX, 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide; sEPSCs, spontaneous excitatory postsynaptic currents.

¹The specified ligand reduces the response (↓), has no effect (Ø), or enhances the response (↑).