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. 2015 Nov 1;11(11):1337–1347. doi: 10.7150/ijbs.12996

Figure 6.

Figure 6

Drug-drug interaction of YZ-LY-0 with other inhibitors of EV71 proliferation. (A) and (B) The anti-EV71 effects of the combination of YZ-LY-0-NITD008 and YZ-LY-0-GPP-3. RD cells were treated with various concentrations of YZ-LY-0, NITD008 or GPP-3 alone, or in combinations and infected with EV71 pseudovirus for 24 h. Antiviral activities were determined by measuring the reduction of luciferase activity in the cells. Each data point represents the average of three replicates in cell culture. (C) and (D) Differential surface plots at the 95% confidence level (CI) were calculated and generated by using MacSynergy II for the drug-drug interaction of the combination of YZ-LY-0-NITD008 (Fig.C) and YZ-LY-0-GPP-3 (Fig.D).The 3-dimensional plot represents the differences between the actual experimental effects and the theoretical additive effects at various concentrations of the two compounds in combination. Only statistically significant(95% CI) differences between the two compounds were considered at any given concentration. Peaks above the theoretical additive plane indicate synergy, whereas depressions below it indicate antagonism. The colors indicate the level of synergy or antagonism.