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. 2015 Nov 1;6(12):1337–1345. doi: 10.7150/jca.13054

Figure 2.

Figure 2

hTERT siRNA and BIBR1532 inhibit cells growth and induce apoptosis. ECC-1 and Ishikawa cells were transfected with hTERT siRNA and treated with BIBR1532 for 48 hours. Cell proliferation was assessed by MTT assay. Inhibition of hTERT decreased cell proliferation (A). ECC-1 and Ishikawa cells were transfected with siRNA for hTERT or treated by BIBR1532 for 24 hours. The apoptosis were detected using Annexin V assay (B) and Western blotting (C). hTERT siRNA or BIBR1532 induced expression of Annexin V and cleaved caspase 3 in both cell lines. Data is shown as mean + SEM of triplicates (*p < 0.05).