Fig. 2.

Phenotypes and cytokine profiles of HLA-DR⁻CD33⁺CD11b⁺ MDSCs in extranodal NK/T cell lymphoma patients. The HLA-DR⁻CD33⁺CD11b⁺ cells are gated as MDSCs from 22 NK/T cell lymphoma patients. The properties of the MDSCs are analyzed via flow cytometry using multiple antihuman mAbs against CD14, CD15, CD66b, iNOS, Arg-1, IL-17, IL-10 and TGFβ. a Representative FACS plots of the CD14⁺ or CD15⁺ MDSCs from the same ENKL patients. b Graph of the CD14⁺ Mo-MDSCs and CD15⁺ PNM-MDSCs among the PBMCs from 22 ENKL patients and 22 healthy controls. c Representative FACS histogram for CD66b, iNOS and Arg-1 expression in ENKL-MDSCs and MDSCs from healthy control. d The data shown are the MFI of CD66b, iNOS and Arg-1 in ENKL-MDSCs from 22 ENKL patients and MDSCs from healthy controls determined by cytofluorimetric analysis and are corrected for background staining. e The percentage of cytokine-producing ENKL-MDSCs from 22 ENKL patients and MDSCs from healthy controls, including IL-17, IL-10 and TGFβ. MFI, mean fluorescence intensity; **P < 0.01; *P < 0.05