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Caloric restriction induced early onset of glucose reduction and ketone bodies increase. (A) CMRglc visual map of the four mice groups. The color code indicates the CMRglc (in SUV) in a linear scale. (B) Quantitative global CMRglc. (C) Quantitative hippocampal CMRglc. (D) Blood glucose. (E) Blood ketone bodies. Data are presented as Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.
