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An overview of the origins of macrophages in the different tissues.
| Tissue-resident macrophages | Embryonic progenitor |
Adult hematopoietic stem cells | |
|---|---|---|---|
| Yolk sac | Fetal liver monocytes | ||
| Spleen (27) | √ | √ | |
| Pancreas (27) | √ | √ | |
| Kidney(27) | √ | √ | |
| Brain (microglia) (41) | √ | ||
| Heart (31) | √ | √ | √ (small number) |
| Skin (Langerhans cells) (30) | √ | ||
| Skin (dermal macrophages) (42, 43) | √ | ||
| Gut (39, 40) | √ | ||
| Lung (alveolar macrophages) (25) | √ | ||
| Liver (Kupffer cell) (28, 44) | √ | √ | |
