Table 1.
An overview of the origins of macrophages in the different tissues.
Tissue-resident macrophages | Embryonic progenitor |
Adult hematopoietic stem cells | |
---|---|---|---|
Yolk sac | Fetal liver monocytes | ||
Spleen (27) | √ | √ | |
Pancreas (27) | √ | √ | |
Kidney(27) | √ | √ | |
Brain (microglia) (41) | √ | ||
Heart (31) | √ | √ | √ (small number) |
Skin (Langerhans cells) (30) | √ | ||
Skin (dermal macrophages) (42, 43) | √ | ||
Gut (39, 40) | √ | ||
Lung (alveolar macrophages) (25) | √ | ||
Liver (Kupffer cell) (28, 44) | √ | √ |