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. 2015 Nov 13;6:240. doi: 10.3389/fneur.2015.00240

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Copyright © 2015 Smith, Xiong, Elkind, Putnam and Cohen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alterations in layer 2/3 intrinsic excitability following LFPI. (A) Representative traces from layer 2/3 neurons showing voltage response to selected current steps (−50, 0, 50, 175 pA). Response to 175 pA current step shown in black for visual clarity. Note the decreased firing rate in the LFPI trace. (B) Group data displaying no change in resting membrane potential after LFPI. (C) Group data illustrating no difference in input resistance after LFPI. (D) Frequency versus current group data showing an increase in firing rate following LFPI. (E) Action potential threshold is significantly depolarized in slices derived from LFPI animals (* indicates P < 0.05). (F) Action potential half-width is unchanged following LFPI.