Table 3. Previous studies comparing NLR and bladder cancer staging.
| Source | Patient | NLR | Analysis |
|---|---|---|---|
| Can et al. (2012) [9] | 182 Patients: NMIBC (n=80), MIBC (n=102) | ROC cutoff: 2.57 | NLR>2.57 was independent predictor of MIBC (OR, 2.78; 95% CI, 1.383-5.588; p=0.004*) |
| Ceylan et al. (2014) [10] | 198 Patients: NMIBC (n=162), MIBC (n=36) | Mean NLR: MIBC, 4.14±2.76; NMIBC, 3.36±2.88 | Mean NLR differed significantly between MIBC and NMIBC on Mann-Whitney U test (p=0.03*) |
| ROC cutoff: 3.96 | |||
| Kaynar et al. (2014) [11] | 291 Patients: NMIBC (n=192), MIBC (n=99) | Mean NLR: MIBC, 2.9±0.2; NMIBC, 2.4±0.1 | Mean NLR differed significantly between MIBC and NMIBC on Mann-Whitney U test (p=0.028*) |
| Significant correlation between NLR and MIBC on univariate analysis (r=0.138, p=0.031*) | |||
| Krane et al. (2013) [21] | 68 Patients with recurrent T1 disease or MIBC undergoing radical cystectomy | Mean NLR: 4.0±2.8 (overall) | NLR>2.5 was independent predictor of extravesical disease (RR, 3.18; 95% CI, 1.09-9.79; no p-value given) |
| Cutoff: 2.5 (as per previous publications) | |||
| Potretzke et al. (2014) [22] | 102 Patients undergoing radical cystectomy: NMIBC (n=25), MIBC (n=77) | Mean NLR: 4.33±0.87 (upstaged to ≥pT3) and 2.66±0.29 (≤pT2) | NLR (continuous variable) was independent predictor of upstaging (OR, 1.36; 95% CI, 1.01-1.84; p=0.04*) and extravesical dis- ease (OR, 1.5; 95% CI, 1.07-2.1; p=0.02*) at radical cystectomy |
| Viers et al. (2014) [23] | 899 Patients undergoing radical cystectomy: NMIBC (n=363), MIBC (n=524) | Cutoff: 2.7 (obtained visually) | NLR (continuous variable) was independent predictor of extravesical disease (OR, 1.07; 95% CI, 1.01-1.15; p=0.03*) and lymph node involvement (OR, 1.09; 95% CI, 1.02-1.16; p=0.02*) |
NLR, neutrophil-to-lymphocyte ratio; NMIBC, nonmuscle invasive bladder cancer; MIBC, muscle invasive bladder cancer; ROC, receiver operating characteristics; OR, odds ratio; CI, confidence interval; RR, relative risk.