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Unfolding of GPIbαN prolongs the bond lifetime. (A and B) Plots of lifetime (mean ± SE of >20 measurements per point) versus force of VWF-A1 bonds with GC (A) or GPIbα on platelets (B). (C) Schematic of the A1-GPIbαN complex in normal state (left) and force, induced a longer-lived state (right). (Horizontal arrows) Tensile forces. To see this figure in color, go online.
