Figure 1.

(a) Homology model of the human TRPM8 TM region, as viewed from the EC side. Each monomer is colored distinctly. (b) Side view of the human TRPM8 TM region. The IC and EC sides have been labeled. (c) Sequence alignment between the TM regions of human TRPV1 and TRPM8. The regions are labeled above the sequence including the predicted Helix-turn-helix segment (between S2 and S3 helices) and the EC-loop between SF and S6 helix. The colors are based on sequence conservation, where dark green represents total conservation and yellow is partial conservation. The EC and IC sides have been labeled accordingly. To see this figure in color, go online.