Figure 2.

Intracellular hydrostatic pressure (Δp) gradients in different types of lenses. (A) Intracellular pressures in lenses from mice (a = 0.10 cm), rats (a = 0.22 cm), rabbits (a = 0.48 cm), and dogs (a = 0.57 cm). Reproduced from Gao et al. (24) with permission from Investigative Ophthalmology & Visual Science, which holds the copyright. When pressures at each radial location (r) were normalized by the radius (a), the profiles were indistinguishable. (B) Intracellular Δp measured in wild-type and PTEN null mouse lenses at 10 weeks of age. Reproduced from Sellitto et al. (25) with the permission from the Journal of Clinical Investigation, which holds the copyright. In PTEN knockout lenses, intracellular Δp in cells at the surface became progressively more positive with age until the lenses began to rupture at 12 weeks of age. There was also a slight reduction in gap-junction coupling, which caused a small increase in the pressure gradient.