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. 2015 Nov 13;5:16516. doi: 10.1038/srep16516

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Abbreviations: OS, overall survival; PTR, primary tumor resection. P_trend values for median overall survival times of PTR and non-PTR patients relative to the year of diagnosis were less than 0.001. The median overall survival time of PTR patients with CRC diagnosed in the year 2010 was not met.