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. 2015 Nov 13;5:15182. doi: 10.1038/srep15182

Figure 2. SET overexpression is sufficient to induce pathological changes in normal prostate epithelium.

Figure 2

(a) Prostate tissue regenerations were constructed using normal (Wt) murine prostate epithelium infected with high titer SET lenti virus (SET-FUCRW) combined with urogenital sinus mesenchyme (UGSM). (b) SET lenti viral infected prostate cells generate larger grafts than control grafts (SET-FUCRW = 104.0 g, control = 38.6 g, p < 0.05) and displayed higher proliferation (SET graft = 17% Ki67, control 1%, p < 0.001). (c) SET lenti infected prostate cells generated grafts with pathologies encompassing hyperplasia to low grade PIN (Fig. 2c–d) (see also Fig S6a, b).