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. 2015 Nov 13;5:15182. doi: 10.1038/srep15182

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(a) Resistant prostate cancer cells show poor response to escalating dosages of enzalutamide in vitro [IC₅₀ (μM): 22RV1 = 35.7, C42 = 37.7, LNCaP^ENZ−RES= 35.3 and PC3 = 45.73] but are (b,c) highly responsive to OP449 [IC50s (μM): 22RV1 = 5.62, C42 = 2.16, LNCaP^ENZ−RES, PC3 = 0.67] and (d) in vivo using PC3 cell tumorigenic assays measured by volume or (e) average tumor weight (n=6, treatment starting on day 9, final volume at day 24).