Table 1. Dose-effect values of single drugs.
| Cell type | Individual Drug | Dose-effect values |
|||
|---|---|---|---|---|---|
| EC50 | EC75 | EC90 | EC95 | ||
| J89GFP | BRY (μM) | 0.5 ± 0.18 | 2.02 ± 0.76 | 8.23 ± 3.41 | 21.48 ± 9.58 |
| PNB (nM) | 49.85 ± 12.65 | 80.31 ± 25.32 | 130.36 ± 50.69 | 182.04 ± 80.92 | |
| RMD (nM) | 12.88 ± 2.88 | 20.17 ± 5.17 | 31.87 ± 10.13 | 43.72 ± 16.42 | |
| THP89GFP | BRY (nM) | 17.3 ± 8.7 | 31.4 ± 9.8 | 62.6 ± 23.3 | 105.5 ± 55.6 |
| PNB (nM) | 19.34 ± 6.43 | 28.87 ± 10.41 | 44.19 ± 18.99 | 60.02 ± 30.38 | |
| RMD (nM) | 10.55 ± 4.09 | 19.07 ± 6.9 | 35.83 ± 14.04 | 56.7 ± 27.87 | |
The effective concentration (EC) for each drug after a 24-hour treatment of J89GFP and THP89GFP cells normalized to TNF-induced viral reactivation. Data are mean ± SD from at least six independent experiments performed in triplicate.