Table 1.
Hospital admission (T1) vs. hospital discharge (T2): differences in microbial taxa and diversity measures in females with AN (n=10)
| Taxonomic/diversity level |
Classification | Test statistic |
p | FDR corrected p |
|---|---|---|---|---|
| Global Tests | ||||
| Phylum | 2.66 | 0.042 | ||
| Class | 2.14 | 0.067 | ||
| Order | 1.77 | 0.064 | ||
| Family | 1.70 | 0.064 | ||
| Genus | 1.74 | 0.041 | ||
| Beta diversity | Weighted | 1.50 | 0.22 | |
| Unweighted | 6.07 | 0.0003 | ||
| Univariate Tests | ||||
| Family | Eubacteriaceae | −3.5 | 0.039 | 0.63 |
| Genus | Ruminococcaceae_genus | −26.5 | 0.004 | 0.10 |
| Oscillospira | −22.5 | 0.020 | 0.34 | |
| Ruminococcus | 27.5 | 0.002 | 0.10 | |
| Beta diversity | Unweighted (PC 5) | −23.5 | 0.014 | 0.070 |
| Unweighted (PC 6) | −21.5 | 0.027 | 0.090 | |
| Unweighted (PC 10) | 26.5 | 0.004 | 0.040 | |
a
FDR = false discovery rate; PC = principal coordinate
b
Alpha = 0.05; FDR level = 0.1
c
A global multivariate test (59) was used to test for differences in alpha diversity, beta diversity, and abundance per taxonomic level. Depending on the symmetry of the distribution of the paired differences, differences were tested at the univariate level using Wilcoxon matched pairs rank test (−2 ≤ skewness ≤ 2) or the sign test (skewness ≤ −2 or ≥ 2).