Fig. 3. Development of ACF in mice with different genetic background.
The number of aberrant crypt foci (ACF) was visualized after special staining (see methods for details). No ACFs were observed in Xpc−/−and the normal control mice, while Xpc−/−KrasLA1 mice had a significantly higher number of ACF than those from Xpc+/+KrasLA1 mice (P value < 0.05).