Table 1.

Necessary Content Identified in the Literature

Code	Jenkins	Tomamichel	Rodenhuis
Is research		Used in animals and a few humans*	Experimental – first in humans
Prognosis	Prognosis
Treatment options	Other treatment or care options	Lack of proven treatments
Aims	Major aims		Objective is to further therapy progress
Benefit unknown	Probable lack of therapeutic benefits	Anti-tumor effect unknown/unlikely*	Effect on tumor uncertain. Cure improbable
Extra Procedures	Extra blood draws, frequent visits	Extra Research Procedures
Unknown AEs	Unknown adverse effects	Limited knowledge of side effects*	Side effects expected, may be serious
Voluntary	Voluntary		Voluntary*
Withdraw	Can withdraw	Can withdraw*	Can withdraw
Questions			Consent given and questions answered

^*Mentioned by Willems